browser-use · Browser Use Inc. (YC-backed, SF)
★ 103,000 · highMIT-licensed Python library (103k stars) that lets any LLM drive a real Chrome browser via DOM+vision instead of brittle selectors, now flanked by a desktop app and a usage-based cloud with stealth browsers, proxies, and a 24/7 'Browser Use Box' agent.
General / computer-useopen-sourcebyok✓ mcp✓ local models⛨ optional
OpenAI's open-source (Apache-2.0) Rust-rewritten terminal coding agent, distinguished by kernel-level OS sandboxing (Apple Seatbelt on macOS, Landlock/seccomp on Linux), a 272K-1M token context with GPT-5.x Codex models, MCP support, and cloud handoff to Codex web tasks.
Vendor CLI agentsopen-sourcesubscription✓ mcp✓ local models⛨ os-sandbox
OpenHands · All Hands AI / OpenHands
★ 79,895 · highFormerly OpenDevin, the leading open-source autonomous software-engineering platform: Docker-sandboxed agents that write code, run commands, browse, and open PRs, with a production agent SDK hitting 72% on SWE-bench Verified (Claude Sonnet 4.5) and its own broader OpenHands Index benchmark launched Jan 2026.
OSS coding harnessesopen-sourcefreemium✓ mcp✓ skills✓ local models⛨ container
Warp · Warp (warpdotdev)
★ 62,928 · mediumWarp is a Rust-based GPU-accelerated 'Agentic Development Environment' (terminal app, source opened April 2026 under dual MIT/AGPL) distinguished by running multiple agents in parallel — including hosting Claude Code, Codex, and Gemini CLI — plus Oz, its cloud orchestrator for autonomous background agents, with BYOK and credit-based pricing.
Vendor CLI agentsopen-sourcefreemium✓ mcp⛨ cloud-remote
CrewAI · CrewAI Inc.
★ 55,117 · highMIT-licensed Python framework (~55k stars) for role-based multi-agent 'Crews' plus event-driven 'Flows', with unified memory, hierarchical delegation, and a commercial AMP cloud platform (free tier, Pro from ~$25/mo, enterprise) that CrewAI says powered ~2B agentic executions in the year to January 2026.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional
Low-level graph-based agent orchestration runtime with automatic checkpointing, durable execution, human-in-the-loop interrupts, and streaming (v1.2 in May 2026 added typed streaming, per-node timeouts, and distributed runtime), used in production by Klarna, LinkedIn, Uber, and Replit and serving as the substrate under Deep Agents.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models
Mastra · Mastra (Gatsby founders)
★ 25,927 · highThe leading TypeScript agent framework (Apache 2.0 core since July 2025; some enterprise features commercial) offering agents, type-safe workflows with suspend/resume human-in-the-loop, memory, a unified router to 3,300+ models across ~94 providers, guardrails/scorers/tracing, Mastra Studio for interactive testing, and file-based agent definitions added July 2026.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models
Kilo CLI · Kilo (Kilo Code)
★ 25,785 · mediumKilo's open-source terminal agent (Kilo CLI 1.0, built on the MIT-licensed OpenCode foundation) distinguished by support for 500+ models with zero-markup BYOK pricing, an MCP marketplace, and cross-surface continuity where a task can move between Slack, VS Code/JetBrains, cloud, and terminal.
Vendor CLI agentsopen-sourcebyok✓ mcp✓ local models
Letta · Letta (formerly MemGPT, UC Berkeley spinout)
★ 23,701 · highApache-2.0 platform for stateful agents descended from MemGPT, distinguished by tiered self-editing memory persisted in a database (core memory in-context, archival out-of-context) plus 2026 research on git-based 'Context Repositories' and memory-native RL; in 2026 the company is consolidating around Letta Code, an open, model-agnostic memory-first coding agent harness (LettaBot archived May 2026 and folded in as Channels).
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional
The AutoGen + Semantic Kernel convergence (1.0 GA April 2026) for .NET and Python, whose BUILD 2026 'Agent Harness' made production patterns first-class — shell/filesystem access, human-in-the-loop approvals, context compaction, todo tracking, plan/execute modes, AgentSkillsProvider skill discovery, and BackgroundAgentsProvider subagents — with hosted execution via Microsoft Foundry.
Runtimes & SDKsopen-sourcebyok✓ mcp✓ skills✓ local models⛨ optional