CrewAI · CrewAI Inc.
★ 55,117 · highMIT-licensed Python framework (~55k stars) for role-based multi-agent 'Crews' plus event-driven 'Flows', with unified memory, hierarchical delegation, and a commercial AMP cloud platform (free tier, Pro from ~$25/mo, enterprise) that CrewAI says powered ~2B agentic executions in the year to January 2026.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional
Low-level graph-based agent orchestration runtime with automatic checkpointing, durable execution, human-in-the-loop interrupts, and streaming (v1.2 in May 2026 added typed streaming, per-node timeouts, and distributed runtime), used in production by Klarna, LinkedIn, Uber, and Replit and serving as the substrate under Deep Agents.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models
Mastra · Mastra (Gatsby founders)
★ 25,927 · highThe leading TypeScript agent framework (Apache 2.0 core since July 2025; some enterprise features commercial) offering agents, type-safe workflows with suspend/resume human-in-the-loop, memory, a unified router to 3,300+ models across ~94 providers, guardrails/scorers/tracing, Mastra Studio for interactive testing, and file-based agent definitions added July 2026.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models
Alibaba's Apache-2.0 terminal agent (originally a Gemini CLI fork) optimized for Qwen3-Coder models, distinguished by broad provider flexibility (OpenAI/Anthropic/Gemini/Qwen APIs plus Ollama/vLLM local models), skills/subagents primitives, headless mode, and TypeScript/Python/Java SDKs.
Vendor CLI agentsopen-sourcefreemium✓ mcp✓ skills✓ local models
Letta · Letta (formerly MemGPT, UC Berkeley spinout)
★ 23,701 · highApache-2.0 platform for stateful agents descended from MemGPT, distinguished by tiered self-editing memory persisted in a database (core memory in-context, archival out-of-context) plus 2026 research on git-based 'Context Repositories' and memory-native RL; in 2026 the company is consolidating around Letta Code, an open, model-agnostic memory-first coding agent harness (LettaBot archived May 2026 and folded in as Channels).
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional