CrewAI · CrewAI Inc.
★ 55,117 · highMIT-licensed Python framework (~55k stars) for role-based multi-agent 'Crews' plus event-driven 'Flows', with unified memory, hierarchical delegation, and a commercial AMP cloud platform (free tier, Pro from ~$25/mo, enterprise) that CrewAI says powered ~2B agentic executions in the year to January 2026.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional
Low-level graph-based agent orchestration runtime with automatic checkpointing, durable execution, human-in-the-loop interrupts, and streaming (v1.2 in May 2026 added typed streaming, per-node timeouts, and distributed runtime), used in production by Klarna, LinkedIn, Uber, and Replit and serving as the substrate under Deep Agents.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models
Hugging Face's minimalist (~1,000-line core, Apache 2.0) 'agents that think in code' harness where the model writes executable Python as its action format instead of JSON tool calls, model-agnostic via transformers/Ollama/LiteLLM, with optional sandboxed execution (E2B, Docker, WebAssembly), managed sub-agents, and Hub sharing of tools and agents.
Runtimes & SDKsopen-sourcebyok✓ mcp✓ local models⛨ optional
OpenAI's agent harness whose April 15, 2026 overhaul added a 'model-native harness' with Codex-like filesystem/shell tools, built-in compaction and memory, snapshot/rehydrate durable execution, handoffs, guardrails, tracing, and native sandbox execution via bring-your-own or built-in providers (E2B, Modal, Daytona, Cloudflare, Vercel, Blaxel, Runloop); non-OpenAI models supported via LiteLLM and Chat Completions-compatible endpoints.
Runtimes & SDKsopen-sourceusage-based✓ mcp✓ local models⛨ optional
Mastra · Mastra (Gatsby founders)
★ 25,927 · highThe leading TypeScript agent framework (Apache 2.0 core since July 2025; some enterprise features commercial) offering agents, type-safe workflows with suspend/resume human-in-the-loop, memory, a unified router to 3,300+ models across ~94 providers, guardrails/scorers/tracing, Mastra Studio for interactive testing, and file-based agent definitions added July 2026.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models
LangChain's self-described 'batteries-included agent harness' (GA March 2026, ~26k stars) for long-running tasks, layering planning via write_todos, a virtual filesystem for context offloading, SKILL.md-compatible skills with progressive disclosure, subagent spawning, and LangGraph-store-backed long-term memory on top of the LangGraph runtime.
Runtimes & SDKsopen-sourcebyok✓ mcp✓ skills✓ local models⛨ optional
Letta · Letta (formerly MemGPT, UC Berkeley spinout)
★ 23,701 · highApache-2.0 platform for stateful agents descended from MemGPT, distinguished by tiered self-editing memory persisted in a database (core memory in-context, archival out-of-context) plus 2026 research on git-based 'Context Repositories' and memory-native RL; in 2026 the company is consolidating around Letta Code, an open, model-agnostic memory-first coding agent harness (LettaBot archived May 2026 and folded in as Channels).
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional
MIT-licensed, type-safe Python agent framework from the Pydantic team with a FastAPI-like developer experience: schema-validated structured outputs, first-class MCP support, built-in OpenTelemetry observability (pairs with Logfire), and durable execution via native Temporal/DBOS integrations that offload model requests, tool calls, and MCP communication to fault-tolerant activities.
Runtimes & SDKsopen-sourcebyok✓ mcp✓ local models⛨ optional
OpenHarness (Ohmo) · HKUDS (University of Hong Kong Data Intelligence Lab)
★ 14,635 · mediumMIT-licensed open agent harness from HKU's Data Intelligence Lab (agent loop, tool registry, permission system, hooks, skills, plugins, MCP, React TUI, automatic context compression) built for clarity and Claude-style workflow compatibility, shipping with 'Ohmo', a built-in personal agent that runs on existing Claude Code/Codex subscriptions and works via Feishu/Slack/Telegram/Discord, autonomously branching, coding, testing, and opening PRs.
Runtimes & SDKsopen-sourcefree✓ mcp✓ skills
The AutoGen + Semantic Kernel convergence (1.0 GA April 2026) for .NET and Python, whose BUILD 2026 'Agent Harness' made production patterns first-class — shell/filesystem access, human-in-the-loop approvals, context compaction, todo tracking, plan/execute modes, AgentSkillsProvider skill discovery, and BackgroundAgentsProvider subagents — with hosted execution via Microsoft Foundry.
Runtimes & SDKsopen-sourcebyok✓ mcp✓ skills✓ local models⛨ optional
Anthropic's production agent library exposing the same harness that powers Claude Code (tool loop, file/bash/web tools, subagents, hooks, skills, MCP, permission checkpoints) in Python and TypeScript; the MIT-licensed SDK wraps the bundled Claude Code runtime and, as of 2026, underpins Anthropic Managed Agents with separate metered billing from June 15, 2026.
Runtimes & SDKsopen-sourceusage-based✓ mcp✓ skills⛨ optional
AWS's fully managed, configuration-defined agent harness (GA June 17, 2026): two API calls (CreateHarness/InvokeHarness) stand up an agent with its own isolated session environment, filesystem and shell, cross-session memory, a curated skills catalog, and web browsing, running any Bedrock, OpenAI, Gemini, or LiteLLM-compatible model with mid-session provider switching and no separate harness charge.
Runtimes & SDKsproprietaryusage-based✓ mcp✓ skills⛨ vm