browser-use · Browser Use Inc. (YC-backed, SF)
★ 103,000 · highMIT-licensed Python library (103k stars) that lets any LLM drive a real Chrome browser via DOM+vision instead of brittle selectors, now flanked by a desktop app and a usage-based cloud with stealth browsers, proxies, and a 24/7 'Browser Use Box' agent.
General / computer-useopen-sourcebyok✓ mcp✓ local models⛨ optional
CrewAI · CrewAI Inc.
★ 55,117 · highMIT-licensed Python framework (~55k stars) for role-based multi-agent 'Crews' plus event-driven 'Flows', with unified memory, hierarchical delegation, and a commercial AMP cloud platform (free tier, Pro from ~$25/mo, enterprise) that CrewAI says powered ~2B agentic executions in the year to January 2026.
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional
The Cline/Roo merger-fork turned all-in-one agentic platform (~26k stars, 3M+ users): IDE extension, CLI, and hosted KiloClaw background agent reachable via Telegram/Discord/Slack, with 500+ models, mid-task model switching, an MCP marketplace, subagents (GA April 2026), and optional Kilo Pass credits from $19/mo.
OSS coding harnessesopen-sourcefreemium✓ mcp✓ local models⛨ optional
Letta · Letta (formerly MemGPT, UC Berkeley spinout)
★ 23,701 · highApache-2.0 platform for stateful agents descended from MemGPT, distinguished by tiered self-editing memory persisted in a database (core memory in-context, archival out-of-context) plus 2026 research on git-based 'Context Repositories' and memory-native RL; in 2026 the company is consolidating around Letta Code, an open, model-agnostic memory-first coding agent harness (LettaBot archived May 2026 and folded in as Channels).
Runtimes & SDKsopen-sourcefreemium✓ mcp✓ local models⛨ optional
The AutoGen + Semantic Kernel convergence (1.0 GA April 2026) for .NET and Python, whose BUILD 2026 'Agent Harness' made production patterns first-class — shell/filesystem access, human-in-the-loop approvals, context compaction, todo tracking, plan/execute modes, AgentSkillsProvider skill discovery, and BackgroundAgentsProvider subagents — with hosted execution via Microsoft Foundry.
Runtimes & SDKsopen-sourcebyok✓ mcp✓ skills✓ local models⛨ optional
Copilot's agent mode inside VS Code (extension itself MIT open-sourced; backend service proprietary) iterates on errors, runs tools/terminal, and applies multi-file edits, distinguished by deep GitHub-ecosystem reach: MCP support, SKILL.md Agent Skills (added April 2026), custom .agent.md agents, a multi-vendor model picker with Ollama BYOK, and a cloud 'coding agent' that works issues into PRs on GitHub Actions.
IDE & desktopopen-sourcefreemium✓ mcp✓ skills✓ local models⛨ optional